FGF signaling facilitates postinjury recovery of mouse hematopoietic system
نویسندگان
چکیده
منابع مشابه
FGF signaling facilitates postinjury recovery of mouse hematopoietic system.
Previous studies have shown that fibroblast growth factor (FGF) signaling promotes hematopoietic stem and progenitor cell (HSPC) expansion in vitro. However, it is unknown whether FGF promotes HSPC expansion in vivo. Here we examined FGF receptor 1 (FGFR1) expression and investigated its in vivo function in HSPCs. Conditional knockout (CKO) of Fgfr1 did not affect phenotypical number of HSPCs a...
متن کاملHEMATOPOIESIS AND STEM CELLS FGF signaling facilitates postinjury recovery of mouse hematopoietic system
1Stowers Institute for Medical Research, Kansas City, MO; 2Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS; 3Department of Immunology, Weizmann Institute of Science, Rehovot, Israel; 4Centre for Stem Cell Research, Christian Medical College, Vellore, India; and 5National Institute of Diabetes and Digestive and Kidney Diseases, National Insti...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-11-393991